Primary Pleomorphic Liposarcoma of the Kidney: A Rare Case Report
Categories :
Case Report , Kidney Tumors , Oncology , The Operating Room Global , The Operating Room Global Journal , TORGJ , TORGJ Vol 2 Issue 2 , Urologic Oncology
Tags : Case ReportDiagnostic ChallengesKidney TumorsMalignant Mesenchymal TumorsOriginal ResearchPleomorphic LiposarcomaPrimary Pleomorphic LiposarcomaRare CaseRare Kidney TumorsRenal LiposarcomaRenal NeoplasmsRetroperitoneal TumorsSoft Tissue SarcomaSurgical ManagementThe Operating Room GlobalThe Operating Room Global JournalTORGJTORGJ Vol 2 Issue 2 2026Urologic Oncology
Article DOI: https://doi.org/10.64573/torgj2605006
Authors: Abdul Haseeb1,3*, Liaqat Ali2, Jamal Ahmad Shah1
1 Postgraduate Resident, Department of Urology, Institute of Kidney Diseases Peshawar, Pakistan.
2 Professor of Urology, Department Team C, Institute of Kidney Diseases Peshawar, Pakistan.
3 The Operating Room Global (TORG).
Cite:
- APA (7th edition): Haseeb, A., Ali, L., & Shah, J. A. (2026, June 10). Primary pleomorphic liposarcoma of the kidney: A rare case report. The Operating Room Global Journal (TORGJ), 2(2). https://doi.org/10.64573/torgj2605006
- Harvard: Haseeb, A., Ali, L. and Shah, J.A., 2026. Primary pleomorphic liposarcoma of the kidney: A rare case report. The Operating Room Global Journal (TORGJ), 2(2). Published 10 June. Available at: https://doi.org/10.64573/torgj2605006
- Vancouver: Haseeb A, Ali L, Shah JA. Primary pleomorphic liposarcoma of the kidney: A rare case report. The Operating Room Global Journal (TORGJ). 2026 Jun 10;2(2). https://doi.org/10.64573/torgj2605006
- MLA (9th edition): Haseeb, Abdul, Liaqat Ali, and Jamal Ahmad Shah. “Primary Pleomorphic Liposarcoma of the Kidney: A Rare Case Report.” The Operating Room Global Journal (TORGJ), vol. 2, no. 2, 10 June 2026, https://doi.org/10.64573/torgj2605006
- Chicago (Author-Date): Haseeb, Abdul, Liaqat Ali, and Jamal Ahmad Shah. 2026. “Primary Pleomorphic Liposarcoma of the Kidney: A Rare Case Report.” The Operating Room Global Journal (TORGJ) 2 (2), June 10. https://doi.org/10.64573/torgj2605006
*Corresponding Author:
Dr. Abdul Haseeb
[email protected]
ORCID ID: 0000-0002-7942-4062
Declaration:
Authors’ Contribution:
AH wrote the first draft of the manuscript. All authors reviewed and edited the manuscript and approved the final version of the manuscript.
Conflict of Interest:
No conflict of interests.
Funding:
No funding received by the authors.
| Article History: |
| Received: 14-05-2026 Accepted: 09-06-2026 |
| Available Online: 10-06-2026 |
| QR Code Access to this Article |
| ABSTRACT |
| Background: Liposarcomas are rare malignant soft tissue sarcomas. Renal liposarcoma accounts for only 1-2% of primary renal sarcomas and is an exceptionally rare entity. Patients commonly present with renal mass, flank pain, or respiratory symptoms. The prognosis remains poor, with reported 5-year survival rates ranging from 29% to 39% following surgical treatment. Case presentation: A 63-year-old male presented to the outpatient department with persistent left flank pain and malaise. He reported vague left-sided abdominal discomfort for one year, associated with an unintentional weight loss of 10 kg over the preceding six months and occasional difficulty in urination. Clinical findings and investigations: Laboratory investigations revealed significant anemia (hemoglobin 8.5 g/dL), while renal function tests were within normal limits. Urinalysis showed numerous red blood cells and 2-3 pus cells per high-power field, with a negative urine culture. Ultrasonography demonstrated a large left renal mass. Contrast-enhanced computed tomography (CT) of the abdomen and pelvis revealed an 8 × 10 cm heterogeneously enhancing mass with central necrosis replacing most of the left kidney, raising suspicion for renal cell carcinoma. Intervention and outcome: Following optimization with blood transfusions and preoperative assessment, the patient underwent an open left radical nephrectomy via a transperitoneal approach. Recovery was uneventful. Histopathological examination confirmed a high-grade pleomorphic liposarcoma arising from the renal parenchyma with negative surgical margins. Immunohistochemistry was negative for Desmin, HMB45, SMA, and PAX8, while EMA showed focal positivity. The patient was referred to medical oncology for further management and remained free of postoperative complications during one month of follow-up. Conclusion: Given the rarity of renal pleomorphic liposarcoma and the limited available literature, reporting such cases is important. Long-term follow-up and accumulation of clinical data may help improve understanding, management strategies, and patient outcomes. Keywords: Case report, Pleomorphic Liposarcoma, Renal Cell Carcinoma Mimic |
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