Predictors of Keloid Recurrence Following Surgical Excision: Clinical, Surgical, and Molecular Determinants
Tags : Clinical DeterminantsDermatologic SurgeryFibroproliferative DisordersKeloid RecurrenceKeloidsMolecular MarkersPlastic and Reconstructive SurgeryReview ArticleRisk FactorsScar FormationSurgical ExcisionSurgical TechniquesThe Operating Room GlobalThe Operating Room Global JournalTORGJVolume 2 Issue 1 2026Wound Healing
Article DOI: https://doi.org/10.64573/torgj2602004
Authors: Ishaan Bakshi1*, Debshree Pattnaik2, Parikshta Sookrah3, Hriday Singh Rawat1,4, Savant Choudhary4
| 1The Operating Room Global (TORG) 2Prasad Institute of Medical Sciences 3Elevé Aesthetic Clinic, Mauritius 4University of Technology, Mauritius |
Cite:
- APA (7th edition): Bakshi, I., Pattnaik, D., Sookrah, P., Rawat, H. S., & Choudhary, S. (2026, February 28). Predictors of keloid recurrence following surgical excision: Clinical, surgical, and molecular determinants. The Operating Room Global Journal (TORGJ), 2(1). https://doi.org/10.64573/torgj2602004
- Harvard: Bakshi, I., Pattnaik, D., Sookrah, P., Rawat, H.S. and Choudhary, S., 2026. Predictors of keloid recurrence following surgical excision: Clinical, surgical, and molecular determinants. The Operating Room Global Journal (TORGJ), 2(1). Published 28 February. Available at: https://doi.org/10.64573/torgj2602004
- Vancouver: Bakshi I, Pattnaik D, Sookrah P, Rawat HS, Choudhary S. Predictors of keloid recurrence following surgical excision: Clinical, surgical, and molecular determinants. The Operating Room Global Journal (TORGJ). 2026 Feb 28;2(1). https://doi.org/10.64573/torgj2602004
- MLA (9th edition): Bakshi, Ishaan, et al. “Predictors of Keloid Recurrence Following Surgical Excision: Clinical, Surgical, and Molecular Determinants.” The Operating Room Global Journal (TORGJ), vol. 2, no. 1, 28 Feb. 2026, https://doi.org/10.64573/torgj2602004
- Chicago (Author-Date): Bakshi, Ishaan, Debshree Pattnaik, Parikshta Sookrah, Hriday Singh Rawat, and Savant Choudhary. 2026. “Predictors of Keloid Recurrence Following Surgical Excision: Clinical, Surgical, and Molecular Determinants.” The Operating Room Global Journal (TORGJ) 2 (1), February 28. https://doi.org/10.64573/torgj2602004
*Corresponding Author:
Dr. Ishaan Bakshi
[email protected]
Declaration:
Authors’ Contribution:
Equal contributions.
Conflict of Interest:
No conflict of interests.
Funding:
No funding received by the authors.
| Article History: |
| Received: 22-02-2026 Accepted: 27-02-2026 |
| Available Online: 28-02-2026 |
| QR Code Access to this Article |
| ABSTRACT |
| Background: Keloids are benign fibroproliferative lesions resulting from abnormal wound healing. Unlike hypertrophic scars, they extend beyond the original injury and rarely regress without treatment. Surgical excision is commonly used for symptomatic or cosmetically unacceptable lesions; however, recurrence rates remain high (45–100%), necessitating structured perioperative strategies to reduce risk. Objective: To synthesize current evidence on predictors of keloid recurrence after surgical excision and propose a risk-stratified framework for operative management. Methods: A narrative review of contemporary literature examining clinical, surgical, and molecular predictors of recurrence was conducted. Results: Younger age, darker Fitzpatrick phototype, family history, and prior recurrence increase risk. Lesion size, chronicity, and location in high-tension areas further contribute to recurrence. Surgical technique significantly influences long-term outcomes. Although persistent profibrotic signaling drives keloid formation, clinically applicable molecular predictive biomarkers remain underdeveloped. Conclusion: Keloid recurrence reflects persistence of a pathological wound microenvironment rather than surgical failure alone. Effective management requires a multifaceted, risk-based approach with ongoing follow-up. Keywords: Keloid; Recurrence; Surgical Excision; Risk Factors; Wound Healing; Adjuvant Therapy |
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