Mucinous Appendiceal Adenocarcinoma Mimicking a Bladder Tumor: A Case Report

June 21, 2026 torgjournaladmin 0
Categories : Adenocarcinoma , Case Report , Gastrointestinal Oncology , Histopathological Diagnosis , Oncology , The Operating Room Global , The Operating Room Global Journal , TORGJ , TORGJ Vol 2 Issue 2 , Urologic Oncology
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Article DOI: https://doi.org/10.64573/torgj2605005

Authors: Maaz Khan1, Nasir Khan2, Abdul Haseeb3,5*, Riaz Ahmed Khan4

1 Postgraduate Resident Department of Urology, Institute of Kidney Diseases Peshawar, Pakistan.
2 Assistant Professor, Department of Urology, Bacha Khan Medical Complex, Swabi, Pakistan.
3 Postgraduate Resident Department of Urology, Institute of Kidney Diseases Peshawar
4 Associate Professor Department of Urology, Institute of Kidney Diseases Peshawar
5  The Operating Room Global (TORG).

Cite:

  • APA (7th edition): Khan, M., Khan, N., Haseeb, A., & Khan, R. A. (2026, June 21). Mucinous appendiceal adenocarcinoma mimicking a bladder tumor: A case report. The Operating Room Global Journal (TORGJ), 2(2). https://doi.org/10.64573/torgj2605005
  • Harvard: Khan, M., Khan, N., Haseeb, A. and Khan, R.A., 2026. Mucinous appendiceal adenocarcinoma mimicking a bladder tumor: A case report. The Operating Room Global Journal (TORGJ), 2(2). Published 21 June. Available at: https://doi.org/10.64573/torgj2605005
  • Vancouver: Khan M, Khan N, Haseeb A, Khan RA. Mucinous appendiceal adenocarcinoma mimicking a bladder tumor: A case report. The Operating Room Global Journal (TORGJ). 2026 Jun 21;2(2). https://doi.org/10.64573/torgj2605005
  • MLA (9th edition): Khan, Maaz, Nasir Khan, Abdul Haseeb, and Riaz Ahmed Khan. “Mucinous Appendiceal Adenocarcinoma Mimicking a Bladder Tumor: A Case Report.” The Operating Room Global Journal (TORGJ), vol. 2, no. 2, 21 June 2026, https://doi.org/10.64573/torgj2605005
  • Chicago (Author-Date): Khan, Maaz, Nasir Khan, Abdul Haseeb, and Riaz Ahmed Khan. 2026. “Mucinous Appendiceal Adenocarcinoma Mimicking a Bladder Tumor: A Case Report.” The Operating Room Global Journal (TORGJ) 2 (2), June 21. https://doi.org/10.64573/torgj2605005

*Corresponding Author:
Dr. Abdul Haseeb
[email protected]
ORCID ID: 0000-0002-7942-4062
Declaration:
Authors’ Contribution:
MK and AH drafted the manuscript; RAK supervised the study; NK critically reviewed the manuscript. All authors reviewed and approved the final manuscript.
Conflict of Interest:
No conflict of interests.
Funding:
No funding received by the authors.

Article History:
Received: 14-05-2026
Accepted: 15-06-2026
Available Online: 21-06-2026
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ABSTRACT
Background: Appendiceal mucinous adenocarcinoma is a rare malignancy with nonspecific clinical manifestations, making early diagnosis challenging. Most localized tumors are diagnosed incidentally following appendectomy, whereas advanced disease may present with fistula formation or involvement of adjacent organs.
Case Presentation: A 56-year-old nonsmoking male with no significant comorbidities presented with dysuria, gross hematuria with passage of amorphous clots for six months, and pneumaturia for three months. He denied abdominal pain, melena, or bowel obstruction symptoms.
Clinical Findings and Investigations: Urinalysis revealed numerous red blood cells and pus cells, while urine culture grew Escherichia coli. Ultrasonography demonstrated a solid mass along the right lateral bladder wall with extravesical extension. Following treatment of urinary tract infection, cystoscopy revealed a mucin-covered tumor involving the right lateral and anterior bladder walls with evidence of fistula formation. Histopathological examination of cystoscopy biopsy demonstrated mucinous adenocarcinoma of appendiceal origin. Colonoscopy was unremarkable. Contrast-enhanced CT of the chest, abdomen, and pelvis showed a 6.3 × 4.7 cm heterogeneous mass involving the right lateral and anterior bladder walls with both endophytic and exophytic components and loss of fat planes with an adjacent ileal loop.
Intervention and Outcome: Exploratory laparotomy revealed an appendiceal tumor encasing the ileum and infiltrating the urinary bladder, forming a complex fistulizing mass. En bloc appendectomy, partial cystectomy, and ileal resection with primary anastomosis were performed. Histopathology confirmed pT4bN0M0 mucinous adenocarcinoma arising in a tubulovillous adenoma, with direct invasion of the bladder detrusor muscle and ileum. Surgical margins were negative. Follow-up imaging at three months showed no evidence of recurrence.
Conclusion: Appendiceal mucinous adenocarcinoma may rarely present with urological symptoms due to fistula formation and adjacent organ invasion. A multidisciplinary approach is essential for accurate diagnosis and optimal management in such complex cases.
Keywords: Appendiceal Mucinous Adenocarcinoma; Hematuria; Pneumaturia; Fistula, Urinary Bladder Invasion.

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